TABLE V -.
Protein cargo from UM plasma-derived EVs involved in cell proliferation and survival, and metastatic niche organization
| Identified Proteins | Alternative Name | Spectrum Count |
|---|---|---|
| Fibronectin | FINC | 130 |
| Vitronectin | VTNC | 109 |
| Clusterin | CLUS | 57 |
| Integrin alpha-IIb | ITA2B | 30 |
| Endoplasmin | ENPL | 28 |
| Integrin beta-3 | ITB3 | 22 |
| SPARC | SPRC | 22 |
| Nidogen-1 | NID1 | 16 |
| Vinculin | VINC | 14 |
| Tenascin | TENA | 13 |
| Pigment epithelium-derived factor | PEDF | 13 |
| C-reactive protein | CRP | 13 |
| Heat shock protein HSP 90-alpha | HS90A | 10 |
| Fibulin-1 | FBLN1 | 9 |
| Heat shock protein HSP 90-beta | HS90B | 7 |
| Endoplasmic reticulum chaperone BiP | BIP | 7 |
| CD44 antigen OS = Homo sapiens | CD44 | 6 |
| Heat shock cognate 71 kDa protein | HSP7C | 4 |
| Extracellular matrix protein 1 | ECM1 | 3 |
| Plexin domain-containing protein 2 | PXDC2 | 2 |
| Extracellular matrix protein 2 | ECM2 | 2 |
| Beta-parvin | PARVB | 2 |
| Caveolae-associated protein 2 | CAVN2 | 2 |
| Ras-related protein Rab-1A | RAB1A | 1 |
| Hepatocyte growth factor activator | HGFA | 1 |
| Oncoprotein-induced transcript 3 protein | OIT3 | 1 |
| EMILIN-1 | EMIL1 | 1 |
| Vascular endothelial growth factor receptor 3 | VGFR3 | 1 |
| Plexin-B1 | PLXB1 | 1 |
| Integrin beta-1 | ITB1 | 1 |
| Alpha-enolase | ENOA | 1 |
| Protein S100-A8 | S10A8 | 1 |
| Protein S100-A9 | S10A9 | 1 |
Data are derived from three patients (UM-5, UM-6, and UM-8) and samples were run in duplicates.
EV = extracellular vesicle; UM = uveal melanoma.