Table 5.
AUCs for treatment outcomes at weeks 12 and 24.
| Measures | AUC for both ACR50 and PASI50 at week 12 | AUC for both ACR70 and PASI75 at week 24 | ||||||
|---|---|---|---|---|---|---|---|---|
| AUC (95%CIs) | p | AUC difference | p | AUC (95%CIs) | p | AUC difference | p | |
| b-MPO–DNA | 0.74 (0.55–0.93) | 0.047 | Reference | – | 0.88 (0.74–1) | 0.009 | Reference | |
| b-ESR | 0.66 (0.42–0.89) | 0.195 | 0.08 | 0.60 | 0.68 (0.47–0.81) | 0.224 | 0.20 | 0.14 |
| b-CRP | 0.72 (0.5–0.94) | 0.075 | 0.02 | 0.877 | 0.84 (0.69–0.99) | 0.018 | 0.03 | 0.76 |
| ΔMPO–DNA | – | – | – | – | 0.92 (0.8–1) | 0.004 | Reference | |
| ΔESR | – | – | – | – | 0.6 (0.31–0.88) | 0.143 | 0.31 | 0.036 |
| ΔCRP | – | – | – | – | 0.86 (0.7–1) | 0.013 | 0.05 | 0.42 |
| ΔMPO–DNA% | – | – | – | – | 0.92 (0.8–1) | 0.004 | Reference | |
| ΔESR% | – | – | – | – | 0.54 (0.28–0.8) | 0.134 | 0.373 | 0.02 |
| ΔCRR% | – | – | – | – | 0.73 (0.54–0.92) | 0.097 | 0.182 | 0.184 |
Values are presented as areas under curve (95% CIs). Treatment outcomes are referred to the achievement of both ACR50 and PASI50 at week 12 and the achievement of both ACR70 and PASI75 at week 24. Abbreviations: b-MPO–DNA/ESR/CRP, serum MPO–DNA complex/ESR/CRP at baseline; ΔMPO–DNA/ESR/CRP, reduction of serum MPO–DNA/ESR/CRP at 12 weeks in absolute value; ΔMPO–DNA/ESR/CRP%, reduction of serum MPO–DNA/ESR/CRP at 12 weeks in percentage.