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. 2022 Apr 18;11(8):e023974. doi: 10.1161/JAHA.121.023974

Figure 7. Action potential (AP) parameters of controls and angiotensin II type 1 receptor (AT1R) mice at 50 days and 6 months.

Figure 7

Typical AP recorded from isolated atrial myocytes of (A) 50‐day (controls, n=14–15; AT1R, n=10) and (B) 6‐month (controls, n=21; AT1R, n=15) mice. Associated tables show measurements of AP parameters (mean±SEM). AP amplitude (APA) and maximal velocity of AP upstroke (V max) were reduced at both ages by AT1R overexpression (APA: 50 days, *P=0.0012; 6 months, *P=0.0295) (V max: 50 days, *P=0.0002; 6 months, *P<0.0001), while the AP duration at 90% of repolarization (APD90) and the resting membrane potential (RMP) were similar between AT1R and control mice (50 days, P=not significant; 6 months, P=not significant).