Table 3.

Multivariate Cox Regression Analysis of the Primary Outcome (12‐Month Follow‐Up)

Recurrent IS poststroke at 12 mo	Univariate			Multivariate
	HR	95% CI	P value	HR	95% CI	P value
Age	1.072	0.972–1.184	0.165
Men	2.122	0.441–10.218	0.348
Paroxysmal AF	1.774	0.444–7.094	0.418
Body mass index	0.850	0.683–1.056	0.143
Use of NOAC	0.825	0.103–6.598	0.856
Creatinine	0.742	0.139–3.954	0.727
NIH stroke scale	1.105	1.011–1.206	0.027	1.099	1.001–1.206	0.047
CHA2DS2VASc score	1.395	0.880–2.212	0.157
Congestive heart failure	1.603	0.200–12.814	0.657
Hypertension	0.955	0.239–3.818	0.948
Diabetes	1.674	0.449–6.234	0.443
Vascular disease	7.735	1.934–30.933	0.004	6.399	1.574–26.020	0.010
Early rhythm control	0.251	0.063–1.003	0.050	0.215	0.052–0.894	0.035

AF indicates atrial fibrillation; CHA2DS2VASc, congestive heart failure, hypertension, age ≥75 years (2 points), type 1 or 2 diabetes, stroke or transient ischemic attack or thromboembolism (2 points), vascular disease (prior myocardial infarction, peripheral artery disease, or aortic plaque), aged 65–75 years, sex category (female); HR, hazard ratio; IS, ischemic stroke; NIH, National Institutes of Health; and NOAC, nonvitamin K antagonist oral anticoagulant.