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. 2022 Jan 11;11(2):e021726. doi: 10.1161/JAHA.121.021726

Figure 1. Mitochondrial DNA in cell‐free and cellular forms in maternal plasma from pregnancies with preeclampsia and healthy controls.

Figure 1

A, Biological forms of mtDNA assessed in this study, (B) ccf‐mtDNA concentrations (pg/mL) in plasma isolated using lysis buffer (membrane bound ccf‐mtDNA), (C) ccf‐mtDNA concentrations (pg/mL) in plasma isolated without lysis buffer (non‐membrane bound ccf‐mtDNA), (D) cellular mtDNA copies per estimated number of peripheral blood mononuclear cells (PBMCs), Student’s t‐test (B and D), Mann‐Whitney U test (C). B through C, n=18 controls, n=17 preeclampsia; (D) n=16 controls, n=11 preeclampsia. All values presented as median (white line), IQR (black lines). ccf‐mtDNA indicates circulating cell‐free mitochondrial DNA; Ceq, cell equivalent; and PBMC, peripheral blood mononuclear cell. Open squares=gestational age‐matched control; open circles=third trimester pregnancies with preeclampsia. A, was created with Biorender.com.