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. 2022 Jan 13;11(2):e021188. doi: 10.1161/JAHA.121.021188

Figure 1. Murine aging is associated with increased thrombin generation, which is moderately reversed with Gpx1 overexpression.

Figure 1

Thrombin generation was measured using calibrated automated thrombogram in platelet poor plasma in young and aged wild‐type mice as well as littermates overexpressing Gpx1 (glutathione peroxidase‐1 transgenic [Gpx1 Tg]). A, Endogenous thrombin potential (ETP). B, Peak thrombin generation. C, Lag time. Data expressed as mean±SD. *P<0.001 vs young wild type, # P<0.05 vs aged wild type, and $ P<0.05 vs young wild type (2‐way ANOVA with Tukey test). N=7 to 8 in each group.