Figure 5. Treatment of aged C57BL6J mice with DNase 1 blocked development of venous thrombi in vivo.

Young and aged C57BL6J mice were treated with either DNase 1 or heat‐inactivated DNase 1 control, during experimental venous thrombosis. Inferior vena cava was ligated in a stasis model and 48 hours later venous thrombus was harvested. A, Thrombus length. B, Thrombus weight. Kruskal–Wallis with Dunn’s test for multiple comparison. N=9 to 12 in each group.