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. 2022 Jan 13;11(2):e021188. doi: 10.1161/JAHA.121.021188

Figure 7. Human aging is associated with elevated levels of cfDNA.

Figure 7

Components of neutrophil extracellular traps were measured in plasma from young and middle‐aged/older subjects. A, Plasma cell‐free DNA (cfDNA). B, Linear regression analysis of cfDNA with age. C, Plasma citrullinated histone (H3Cit). D, Linear regression analysis of H3Cit with age. Data for (A and C) are presented as mean±SD. *P<0.001 vs young subjects. Unpaired t test was used for (A and C) and linear regression analysis for (B and D). N=27 to 28 for (A), 22 to 23 for (C), 55 for (B), and 45 for (D).