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. 2022 Jan 13;11(2):e021188. doi: 10.1161/JAHA.121.021188

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© 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Platelet poor plasma from young and middle aged/older subjects was treated with either 20 µg/mL of DNase 1 or same dose of heat‐inactivated DNase 1 as control for 60 minutes and endogenous thrombin potential (ETP) was measured. Data are presented as mean±SD. *P<0.01 vs young subjects treated with heat‐inactivated DNase 1, ^# P<0.0001 vs middle aged/older subjects treated with heat‐inactivated DNase 1 (2‐way ANOVA, with Tukey test). N=9 in each group. cfDNA indicates cell‐free DNA.