Table 2.

Association Between Continuous and Categorized eGFRcys, eGFRcreat, and eGFRcreat‐cys and the Risk of Incident AF (n=9288)

eGFR	AF events/Total N	HR (95% CI), Model 1	HR (95% CI), Model 2
Continuous, baseline assessment
eGFRcys, mL/min per 1.73 m2	780/9288	1.11 (1.06–1.17)*	1.08 (1.03–1.14)*
eGFRcreat, mL/min per 1.73 m2	780/9288	1.05 (0.99–1.11)	1.04 (0.98–1.10)
eGFRcreat‐cys, mL/min per 1.73 m2	780/9288	1.10 (1.04–1.16)*	1.07 (1.01–1.14)*
Continuous, repeated assessments †
eGFRcreat, mL/min per 1.73 m2	780/9288	1.03 (0.97–1.09)	1.02 (0.97–1.09)
Categorical, baseline assessment
Categories of eGFRcys
eGFRcys ≥60 mL/min per 1.73 m2	545/7599	Reference	Reference
eGFRcys <60 mL/min per 1.73 m2	235/1689	1.45 (1.21–1.73)*	1.37 (1.14–1.64)*
Categories of eGFRcreat
eGFRcreat ≥60 mL/min per 1.73 m2	657/8422	Reference	Reference
eGFRcreat <60 mL/min per 1.73 m2	123 / 866	1.27 (1.03–1.56)*	1.22 (0.99–1.50)
Categories of eGFRcreat‐cys
eGFRcreat‐cys ≥60 mL/min per 1.73 m2	624/8186	Reference	Reference
eGFRcreat‐cys <60 mL/min per 1.73 m2	156/1102	1.35 (1.11–1.64)*	1.27 (1.04–1.55)

Model 1 is adjusted for age, sex and Rotterdam Study cohort. Model 2 is additionally adjusted for educational level, BMI, smoking, alcohol, serum cholesterol, diabetes, physical activity, and use of cardiac medication. HRs are given per 10 mL/min per 1.73 m² decrease in eGFR. Cox proportional‐hazards models were used to investigate the associations between continuous/categorical eGFR at baseline and incident AF. Joint models were used to investigate the association between repeated assessments of eGFRcreat and incident AF. AF indicates atrial fibrillation; BMI, body mass index; eGFR, estimated glomerular filtration rate; eGFRcreat, eGFR based on serum creatinine; eGFRcreat‐cys, eGFR based on serum creatinine and serum cystatin C; eGFRcys, eGFR based on serum cystatin C; and HR, hazard ratio.

^* P<0.05.

^† Total of 55 917 repeated assessments of eGFR (median of 4 repeated assessments).