Table 3.
Association of Incident CVD and Cancer Events and All‐Cause Mortality With SB Bout Accumulation Patterns Across Percentiles of the Population
|
Incident CVD (n=5017; no. of events=1081; person years=30 425) |
Incident cancer (n=6234; no. of events=440; person years=39 234) |
All‐cause mortality (n=7563; no. of events=612; person years=48 303) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Percentile | p10 | p30 | p60 | p90 | p10 | p30 | p60 | p90 | p10 | p30 | p60 | p90 |
| Usual SB bout duration, min | ||||||||||||
| 10 | 15 | 20 | 30 | 10 | 15 | 20 | 30 | 10 | 15 | 20 | 30 | |
| Model 1 | 1 |
0.98 (0.85–1.13) |
0.95 (0.80–1.13) |
1.05 (0.86–1.27) |
1 |
1.02 (0.80–1.29) |
1.15 (0.85–1.55) |
1.37 (1.01–1.87) |
1 |
0.94 (0.74–1.18) |
1.00 (0.76–1.32) |
1.18 (0.90–1.55) |
| Model 2a | 1 |
0.95 (0.82–1.11) |
0.92 (0.76–1.10) |
0.99 (0.80–1.22) |
1 |
1.07 (0.84–1.36) |
1.21 (0.89–1.64) |
1.47 (1.07–2.02) |
1 |
0.99 (0.77–1.26) |
1.05 (0.78–1.42) |
1.32 (0.98–1.79) |
| Model 3a | 1 |
0.95 (0.81–1.11) |
0.90 (0.74–1.10) |
0.97 (0.76–1.23) |
1 |
1.07 (0.82–1.38) |
1.19 (0.85–1.67) |
1.49 (1.02–2.16) |
1 |
0.94 (0.72–1.21) |
0.94 (0.68–1.29) |
1.04 (0.73–1.46) |
| Alpha | ||||||||||||
| 1.7 | 1.8 | 1.9 | 2 | 1.7 | 1.8 | 1.9 | 2 | 1.7 | 1.8 | 1.9 | 2 | |
| Model 1 | 1 |
0.95 (0.85–1.06) |
0.91 (0.76–1.08) |
0.87 (0.73–1.04) |
1 |
0.85 (0.71–1.02) |
0.71 (0.55–0.93) |
0.70 (0.53–0.92) |
1 |
0.81 (0.70–0.95) |
0.71 (0.57–0.88) |
0.67 (0.52–0.86) |
| Model 2a | 1 |
0.98 (0.88–1.10) |
0.96 (0.80–1.16) |
0.96 (0.80–1.16) |
1 |
0.86 (0.71–1.04) |
0.72 (0.54–0.94) |
0.68 (0.51–0.91) |
1 |
0.80 (0.67–0.96) |
0.69 (0.54–0.88) |
0.63 (0.48–0.84) |
| Model 3a | 1 |
0.99 (0.87–1.11) |
0.97 (0.79–1.19) |
0.97 (0.79–1.21) |
1 |
0.83 (0.68–1.02) |
0.69 (0.51–0.94) |
0.66 (0.47–0.92) |
1 |
0.88 (0.73–1.06) |
0.79 (0.61–1.04) |
0.74 (0.53–1.02) |
Data are hazard ratios and 95% CIs and were fitted with the use of restricted cubic splines (3 evenly spaced knots). Results presented approximate the 10th (reference), 30th, 60th and 90th percentiles across all 3 outcomes for usual SB bout duration=10, 15, 20, 30 minutes and alpha= 1.7, 1.8, 1.9, 2 (unitless; higher values indicate accumulation patterns with relatively more interrupted ST than prolonged ST). Covariates that violated the proportional hazard assumptions (education level; social class, family history of diabetes and CVD) were included as baseline strata. CVD indicates cardiovascular disease; and SB, sedentary behavior.
Model 1 is adjusted for sex and device type (with age as the underlying time scale). Model 2a is adjusted as for model 1 plus education level; social class; smoking status; alcohol intake; baseline history of diabetes or taking diabetes medications (not for cancer); taking medication for hypertension/dyslipidemia (not for cancer outcome), or depression; and family history of CVD (stroke/myocardial infarction), diabetes, or cancer (not CVD or diabetes for cancer outcome). Model 3a includes the same covariates as model 2a and further adjusts for the composition of 24‐hour time use (z1 and z2; with z3 dropped because of collinearity).
Participants with a history of stroke/myocardial infarction or cancer were excluded for all incident CVD or cancer outcome models, respectively. For all‐cause mortality, history of stroke/myocardial infarction or cancer was statistically adjusted for in models 2a and 3a.