Table 2.

Risk of Composite Cardiovascular Events and Total Mortality in the Patient Groups Classified by LDL‐C Levels Without Statin Therapy

Variables	LDL‐C, mg/dL	Number of patients	Events	Duration, person‐year	Rate, /1000 person‐year	HR (95% CI) (Model 1)	P value	HR (95% CI) (Model 2)	P value
Composite events	≥260	487	13	2198	5.91	2.90 (1.69–5.00)	<0.0001	2.40 (1.39–4.13)	<0.0001
	225–259	1936	40	8551	4.68	2.30 (1.69–5.14)		2.04 (1.50–2.78)
	190–224	18 844	354	86 679	4.08	2.01 (1.81–2.23)		1.79 (1.61–1.99)
	<160	2 125 867	26 118	12 672 647	2.06	1		1
MI	≥260	487	6	2201	2.73	4.93 (2.22–10.95)	<0.0001	4.06 (1.83–9.00)	<0.0001
	225–259	1936	16	8563	2.22	4.01 (2.56–6.29)		3.41 (2.17–5.35)
	190–224	18 844	135	86 761	1.56	2.81 (2.37–3.33)		2.42 (2.04–2.88)
	<160	2 125 867	7203	12 688 468	0.57	1		1
Coronary revascularization	≥260	487	6	2202	2.73	4.09 (1.84–9.11)	<0.0001	3.43 (1.54–7.64)	<0.0001
	225–259	1936	24	8564	2.80	4.22 (2.82–6.29)		3.76 (2.52–5.62)
	190–224	18 844	171	86 775	1.97	2.96 (2.55–3.45)		2.67 (2.29–3.11)
	<160	2 125 867	8529	12 692 356	0.67	1		1
Ischemic stroke	≥260	487	6	2199	2.73	2.35 (1.06–5.23)	<0.0001	1.89 (0.85–4.20)	<0.0001
	225–259	1936	16	8554	1.87	1.61 (0.99–2.63)		1.44 (0.88–2.35)
	190–224	18 844	163	96 714	1.88	1.62 (1.38–1.89)		1.44 (1.23–1.68)
	<160	2 125 867	14 918	12 679 185	1.18	1		1
Total mortality	≥260	487	15	2201	6.81	2.36 (1.42–3.91)	<0.0001	2.25 (1.35–3.73)	0.0002
	225–259	1936	30	8565	3.50	1.21 (0.85–1.73)		1.25 (0.88–1.79)
	190–224	18 844	279	86 788	3.21	1.11 (0.99–1.25)		1.11 (0.99–1.25)
	<160	2 125 867	37 663	12 693 956	2.97	1		1

Composite events: MI, coronary revascularization, or ischemic stroke. Model 1: unadjusted. Model 2: adjusted for age, sex, body mass index, diabetes, hypertension, smoking, triglycerides, antiplatelet agents.

P values are from the Wald test for HRs of patient groups. HR indicates hazard ratio; LDL‐C, low‐density lipoprotein‐cholesterol; and MI, myocardial infarction.