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. 2022 Apr 27;11(9):e025171. doi: 10.1161/JAHA.121.025171

Figure 4. Long‐term prognostic implication of ischemia with nonobstructive coronary arteries and coronary microvascular disease.

Figure 4

Symptomatic patients with stable ischemic heart disease who underwent of noninvasive stress tests and intracoronary coronary physiologic assessment were evaluated. The patients were stratified according to the presence of ischemia with nonobstructive coronary arteries and coronary microvascular disease. In the overall population, 28.2% showed positive of noninvasive stress tests results and 45.3% had coronary microvascular disease. Patients with coronary microvascular disease showed a significantly increased risk of major adverse cardiovascular event at 5 years, regardless of noninvasive stress tests results. These findings indicate that the differential prognostic impact of endotype of ischemia with nonobstructive coronary arteries which support the necessity of intracoronary physiologic assessment. CAD indicates coronary artery disease; CMD, coronary microvascular disease; HR, hazard ratio; ILIAS, Inclusive Invasive Physiological Assessment in Angina Syndromes; INOCA, ischemia with nonobstructive coronary arteries; MACE, major adverse cardiovascular event; and NIT, noninvasive stress test.