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. 2022 Jun 14;11(12):e025857. doi: 10.1161/JAHA.122.025857

Figure 4. Genomic distribution of the JQ1 inhibitor target BRD4.

Figure 4

A, Heatmaps illustrating all BRD4 (bromodomain‐containing protein 4) peaks at the promoter (pink) and at intronic/intergenic regions (blue) and their association with histone modifications, RNAP II (RNA polymerase II), and chromatin accessibility as derived from ATAC. B, Genome‐wide localization of all 30 906 BRD4 peaks and (C) the distribution of all BRD4 peaks in distance to the transcription start site of the nearest gene in kilobases (kb). D, Gene ontology analysis of genes associated with BRD4 peaks. E, Significantly enriched transcription factor binding motifs within BRD4 peaks. ATAC indicates assay for transposase‐accessible chromatin.