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. 2022 Jun 14;11(12):e025236. doi: 10.1161/JAHA.121.025236

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© 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Results from the probabilistic sensitivity analysis indicating the probability of the pooled cohort equation (PCE)+polygenic risk score for coronary artery disease (CAD‐PRS) being cost‐effective at different willingness‐to‐pay (WTP) thresholds. Compared with PCE alone, PCE+CAD‐PRS is likely to be cost‐effective with a probability of 94% and 99% at $50 000 WTP threshold and 98% and 99% at $100 000 WTP threshold in 5‐ and 10‐year time horizons, respectively.