Table 3.

Events of CAD and Ischemic Stroke per 10 000 Individuals Screened

Time Horizon	Strategy	CAD	Ischemic Stroke	Events Averted	Cost saved per event averted
5 y	PCE alone	184	31
	PCE+CAD‐PRS	157	29	29	13 000
10 y	PCE alone	344	60
	PCE+CAD‐PRS	297	57	50	36 000

Base case analysis events of coronary artery disease (CAD) and ischemic stroke when the model was applied in 10 000 individuals with borderline or intermediate risk. Pooled cohort equation (PCE)+polygenic risk score for coronary artery disease (CAD‐PRS) had ≈29 and 50 fewer events of CAD and ischemic stroke compared with PCE alone, resulting in a cost savings of $13 000 and $36 000 per event averted in 5‐ and 10‐year time horizons, respectively.