Table 5.

Subgroup Analysis of the 3‐Year New‐Onset AF Prediction Models in Total Validation Cohort Population

Subgroup		No. (%)	AF incidence, %	C‐statistic (95% CI)
				Model 2	Model 3	Model 4
Age, y	<65	79 721 (67.8)	0.51	0.609 (0.585–0.633)	0.676 (0.651–0.701)	0.664 (0.639–0.689)
	≥65	37 802 (32.2)	2.62	0.565 (0.549–0.581)	0.63 (0.612–0.648)	0.619 (0.601–0.637)
Sex	Men	58 838 (50.1)	1.44	0.762 (0.748–0.776)	0.777 (0.763–0.791)	0.773 (0.759–0.787)
	Women	58 685 (49.9)	0.94	0.784 (0.766–0.802)	0.816 (0.800–0.832)	0.814 (0.798–0.830)
Hypertension	Yes	41 178 (35)	2.10	0.691 (0.673–0.709)	0.725 (0.709–0.741)	0.722 (0.704–0.740)
	No	76 345 (65)	0.70	0.810 (0.794–0.826)	0.823 (0.807–0.839)	0.818 (0.802–0.834)
Diabetes	Yes	41 065 (34.9)	1.85	0.718 (0.700–0.736)	0.747 (0.731–0.763)	0.744 (0.726–0.762)
	No	76 458 (65.1)	0.83	0.797 (0.781–0.813)	0.817 (0.803–0.831)	0.814 (0.798–0.830)
eGFR, mL/min per 1.73 ${\mathrm{m}}^2$	≥60	108 543 (92.4)	0.95	0.779 (0.767–0.791)	0.799 (0.787–0.811)	0.795 (0.783–0.807)
	30–60	6486 (5.5)	3.42	0.643 (0.610–0.676)	0.688 (0.655–0.721)	0.676 (0.643–0.709)
	<30	2494 (2.1)	5.65	0.645 (0.602–0.688)	0.648 (0.605–0.691)	0.637 (0.594–0.680)
Heart failure	Yes	1456 (1.2)	8.45	0.572 (0.527–0.617)	0.688 (0.641–0.735)	0.684 (0.637–0.731)
	No	116 067 (98.8)	1.10	0.781 (0.769–0.793)	0.79 (0.778–0.802)	0.786 (0.774–0.798)
Cardiovascular disease	Yes	18 959 (16.1)	2.37	0.686 (0.662–0.710)	0.722 (0.700–0.744)	0.719 (0.697–0.741)
	No	98 564 (83.9)	0.96	0.787 (0.773–0.801)	0.804 (0.792–0.816)	0.801 (0.789–0.813)
Stroke	Yes	6240 (5.3)	2.93	0.67 (0.635–0.705)	0.706 (0.671–0.741)	0.703 (0.668–0.738)
	No	111 283 (94.7)	1.09	0.779 (0.767–0.791)	0.799 (0.787–0.811)	0.795 (0.783–0.807)

AF indicates atrial fibrillation; and eGFR, estimated glomerular filtration rate.