Table 2.
Outcomes in PS–Weighted Patients Stratified by Trial Eligibility
| Control | Early rhythm control | |||||||
|---|---|---|---|---|---|---|---|---|
| No. of events | Person‐years | Event rate | No. of events | Person‐years | Event rate | HR (95% CI) | P value | |
| Overall cohort | n= 82 633 | n=27 106 | ||||||
| Composite | 228 | 2049 | 11.13 | 195 | 2065 | 9.45 | 0.85 (0.75–0.97) | 0.015 |
| Stroke | 37 | 2185 | 1.70 | 24 | 2191 | 1.10 | 0.66 (0.47–0.93) | 0.017 |
| HF | 84 | 2125 | 3.94 | 78 | 2124 | 3.69 | 0.95 (0.76–1.18) | 0.613 |
| MI | 34 | 2203 | 1.52 | 25 | 2188 | 1.16 | 0.76 (0.54–1.08) | 0.127 |
| Mortality | 140 | 2243 | 6.24 | 122 | 2223 | 5.49 | 0.88 (0.75–1.04) | 0.135 |
| Eligible for trial | n=61 641 | n=18 307 | ||||||
| Composite | 165 | 1507 | 10.98 | 143 | 1466 | 9.76 | 0.89 (0.76–1.04) | 0.138 |
| Stroke | 31 | 1598 | 1.94 | 20 | 1560 | 1.27 | 0.67 (0.45–0.98) | 0.041 |
| HF | 56 | 1566 | 3.60 | 56 | 1512 | 3.67 | 1.03 (0.79–1.34) | 0.843 |
| MI | 26 | 1613 | 1.59 | 19 | 1558 | 1.24 | 0.78 (0.53–1.17) | 0.236 |
| Mortality | 102 | 1644 | 6.23 | 86 | 1586 | 5.40 | 0.87 (0.72–1.06) | 0.168 |
| Ineligible for trial | n=20 992 | n=8799 | ||||||
| Composite | 63 | 543 | 11.55 | 52 | 600 | 8.69 | 0.77 (0.60–0.98) | 0.035 |
| Stroke | 6 | 587 | 1.04 | 4 | 631 | 0.69 | 0.67 (0.33–1.34) | 0.254 |
| HF | 27 | 560 | 4.89 | 23 | 611 | 3.73 | 0.79 (0.54–1.15) | 0.214 |
| MI | 8 | 589 | 1.35 | 6 | 630 | 0.94 | 0.71 (0.36–1.41) | 0.330 |
| Mortality | 37 | 599 | 6.25 | 36 | 637 | 5.69 | 0.92 (0.68–1.26) | 0.621 |
The event rate was calculated as the number of events per 100 person‐years. Propensity score (PS) weight was applied when calculating number of events, person‐years, event rates, absolute reduction, and hazard ratios (HRs). HF indicates hospitalization with the diagnosis of heart failure; and MI, hospitalization with the diagnosis of myocardial infarction.