Table 3.

Cause‐specific HRs for MACE According to the Visit‐to‐visit SBP Variability (SD)

	Model 1		Model 2		Model 3		Model 4
Visit‐to‐visit SBP variability (SD), mm Hg	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
SBP variability tertiles
Low (≤6.08)	1.00	…	1.00	…	1.00	…	1.00	…
Middle (6.08–11.14)	1.89 (0.93–3.85)	0.078	1.69 (0.83–3.45)	0.122	1.64 (0.80–3.36)	0.178	1.64 (0.80–3.36)	0.179
High (>11.14)	2.88 (1.48–5.62)	0.002	2.40 (1.22–4.75)	0.012	2.22 (1.12–4.41)	0.023	2.23 (1.12–4.44)	0.022
SBP variability continuous modeling
Per 5‐mm Hg increase	1.28 (1.09–1.50)	0.002	1.23 (1.03–1.48)	0.022	1.20 (1.00–1.44)	0.049	1.21 (1.01–1.45)	0.045

CI indicates confidence interval; HR, hazard ratio; and MACE, major adverse cardiovascular events.

Model 1: unadjusted.

Model 2: adjusted for age, sex, body mass index, smoking history, diabetes, cardiovascular disease, and average systolic blood pressure.

Model 3: Model 2+baseline estimated glomerular filtration rate, serum albumin, low‐density lipoprotein cholesterol, intact parathyroid hormone, high‐sensitivity C‐reactive protein, and urine protein to creatinine ratio.

Model 4: Model 3+number of antihypertensive drugs and statin use.