Table 2.
Distribution of First and Subsequent Acute Cardiovascular Events, Procedures, and Noncardiovascular Death
| Event |
Ticagrelor (n=6930) |
Clopidogrel (n=6955) |
Total (n=13 885) |
|---|---|---|---|
| First cardiovascular and limb event | 1924 | 1954 | 3378 |
| Acute cardiovascular and limb event | 943 | 915 | 1858 |
| Cardiovascular death | 252 | 238 | 490 |
| Nonfatal* | 691 | 677 | 1368 |
| Procedure † | 981 | 1039 | 2020 |
| Noncardiovascular death | 183 | 200 | 383 |
| Second cardiovascular and limb event | 891 | 938 | 1829 ‡ |
| Acute cardiovascular and limb event | 284 | 269 | 553 |
| Cardiovascular death | 72 | 59 | 131 |
| Nonfatal* | 212 | 210 | 422 |
| Procedure † | 607 | 669 | 1276 |
| Noncardiovascular death | 47 | 39 | 86 |
| Third cardiovascular and limb event | 408 | 453 | 861 |
| Acute cardiovascular and limb event | 166 | 161 | 327 |
| Cardiovascular death | 32 | 37 | 69 |
| Nonfatal* | 134 | 124 | 258 |
| Procedure † | 242 | 292 | 534 |
| Noncardiovascular death | 14 | 28 | 42 |
| Fourth and subsequent cardiovascular and limb events | 487 | 545 | 1032 |
| Acute cardiovascular and limb events | 153 | 199 | 352 |
| Cardiovascular death | 34 | 44 | 78 |
| Nonfatal* | 119 | 155 | 274 |
| Procedures † | 334 | 346 | 680 |
| Noncardiovascular death | 22 | 16 | 38 |
| Total cardiovascular and limb events | 3710 | 3890 | 7600 |
| Acute cardiovascular and limb events | 1546 | 1544 | 3090 |
| Cardiovascular death | 390 | 378 | 768 |
| Nonfatal* | 1156 | 1166 | 2322 |
| Procedures † | 2164 | 2346 | 4510 |
| Noncardiovascular death | 266 | 283 | 549 |
Values are given as number.
*
Includes nonfatal myocardial infarction, nonfatal ischemic stroke, acute limb ischemia, unstable angina, and transient ischemic attack.
†
Includes coronary revascularization, carotid revascularization, peripheral revascularization, and amputation for symptomatic peripheral artery disease.
‡
Represents the number of patients with >1 event during the study.