Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 14;15:824956. doi: 10.3389/fnmol.2022.824956

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Mishra, Kinoshita, Axtman and Young.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

SGC-CK2-1 is more effective at inhibiting mRNA expression of IL-6 and IL1-β in hiPSC-MGLs after LPS stimulation than CX-4945. WT (A,B) and FAD (C,D) MGLs were stimulated with LPS and simultaneously treated with either SGC-CK2-1 or CX-4945 for 24 h. In all conditions, SGC-CK2-1 was more effective at inhibiting both IL-6 and IL1-β mRNA than CX-4945. These data represent three independent differentiations. ^****p ≤ 0.0001; ^***p = 0.0006; ^**p = 0.0077; *p = 0.0293; ns, not significant by one-way ANOVA analysis. Error bars indicate the mean ± SD.