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. 2022 Jun 14;15:824956. doi: 10.3389/fnmol.2022.824956

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Copyright © 2022 Mishra, Kinoshita, Axtman and Young.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SGC-CK2-1 reduces pro-inflammatory cytokine secretion more effectively than CX-4945. WT (A,B) and FAD (C,D) MGLs were stimulated with LPS and simultaneously treated with either SGC-CK2-1 or CX-4945 for 24 h. In all conditions, SGC-CK2-1 was more effective at inhibiting both IL-6 and IL1-β cytokine secretion into the culture media than CX-4945. These data represent three independent differentiations. ^****p ≤ 0.0001; ^***p = 0.0006; ^**p = 0.0024 by one-way ANOVA analysis. Error bars indicate the mean ± SD.