FIG 2.

Infection of KO cell lines with a panel of mammarenavirus GP pseudotyped virus. (A to E) Percent infection of ΔCD164, ΔDAG1, and ΔCD164 ΔDAG1 double-KO cells relative to WT in either A549 or 293T cell type backgrounds following inoculation with low-DAG1-affinity LCMV strain Armstrong 53b-GP (A) or WE2.2-GP (B) and high-DAG1-affinity strain Armstrong clone 13-GP (C), W54-GP (D), or WE-GP (E) pseudotyped virus as determined by flow cytometry for GFP positivity. Cells were infected at an MOI of 1 and measured 24 hpi. Error bars indicate standard errors from three independent experiments. (F to H) Percent infection of ΔCD164, ΔDAG1, and ΔCD164 ΔDAG1 double-KO cells relative to WT in either A549 or 293T cell type backgrounds following inoculation with LASV-GP (D), GTOV-GP (E), or MACV-GP (F) pseudotyped virus as determined by flow cytometry for GFP positivity. Cells were infected at an MOI of 1 and measured 24 hpi. Error bars indicate standard errors from three independent experiments.