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Proposed model for the role of CD81 in CHIKV infection. CD81 is a plasma membrane protein that binds to cholesterol and has a cone-like topology. CHIKV nsPs form replication compartments at the plasma membrane, termed spherules, where dsRNA is synthesized during active replication. Our data suggest that CD81 promotes membrane curvature, thereby facilitating CHIKV replication at the plasma membrane. Illustration created with BioRender.com and modified from reference 80 and 105.
