FIG 1.

ELISA binding and FRNT neutralization by human mAbs targeting YFV E protein. (A) Half-maximal effective concentrations (EC₅₀s) of antibody binding to YFV E as determined by ELISAs. Values were interpolated using a nonlinear regression model in Prism software. Data from a single experiment are shown, representative of results from three independent experiments. (B) Focus reduction neutralization test (FRNT) to assess the neutralization of YFV-17D by YFV-121 and YFV-136. Neutralization values were fit to a nonlinear regression model. Data from a single experiment are shown, representing results from at least two independent experiments.