FIG 5.

Syrian golden hamster challenge studies to assess YFV-136 therapeutic efficacy. (A) Kaplan-Meier survival curves of animals (YFV-136, n = 10; DENV-2D22 control, n = 15; uninfected controls, n = 5) treated with 50 mg/kg of YFV-136 or 20 mg/kg of the isotype control 3 days after inoculation with 200 50% cell culture infectious doses (CCID₅₀) of the hamster-adapted YFV Jimenez strain. Statistical analysis was performed using a Wilcoxon log rank test. (B) Weights of YFV-infected animals treated with YFV-136 or isotype control mAb or uninoculated animals throughout the course of the study. (C) Serum virus titers (CCID₅₀) were assessed 6 days after virus inoculation. One-way analysis of variance (ANOVA) with Dunnett’s multiple-comparison posttest was used to assess statistical significance. (D) Serum alanine aminotransferase (ALT) levels 6 days after inoculation were assessed as a proxy for liver damage. One-way ANOVA with Dunnett’s multiple-comparison posttest was used to assess statistical significance; *** indicates p < 0.001, ** indicates. p < 0.01.