TABLE 1.
Effect of delayed treatment (3 dpi) with mAb YFV-136 in a Syrian golden hamster model of YFV Jimenez strain infection and diseasec
| mAb treatment | Dose of mAb given at 3 dpi (mg/kg) | Virus given i.p. at 0 dpi | No. of alive/total no. of animals at 21 dpi | Mean day of death ± SD | Mean body wt changeb (g) ± SD | Mean serum virus titer (CCID50/mL) at 4 dpi ± SD | Mean serum ALT level (IU/L) at 6 dpi ± SD |
|---|---|---|---|---|---|---|---|
| YFV-136 | 50 | YFVa | 10/10 | >21 ± 0.0** | −5.2 ± 6.7 | 4.1 ± 2.2 | 114 ± 26* |
| Isotype control (DENV-2D22) | 10 | YFVa | 3/15 | 7.5 ± 1.4 | −8.9 ± 9.9 | 5.4 ± 2.3 | 214 ± 120 |
| Normal control | — | Sham | 5/5 | >21.0 ± 0.0** | 3.0 ± 2.1** | 1.7 ± 0.0** | 80 ± 3* |
a
Hamster-adapted YFV Jimenez strain (24).
b
Difference between weights at 4 and 5 dpi, representing the maximal weight change in this study.
c
**, P < 0.001; *, P < 0.01 (compared to the control treatment).