FIG 9.
Lysozyme restored microbiota disorders induced by dysfunction of Paneth cells. (A) Representative photographs of H&E staining of the pancreas of ABX mice receiving FMT (n = 6 mice per group). (B) Level of amylase. (C) Representative photographs of H&E staining of the ileum of ABX mice receiving FMT (n = 6 mice per group). (D and E) mRNA expression levels of TNF-α, IL-6, and IL-1β in the pancreas (D) and ileum (E). (F) Principal-coordinate analysis (PCoA) of bacterial beta diversity (n = 4 to 6 mice per group). (G to I) Alpha diversity analysis using the Chao1 index, the Shannon index, and the Simpson index. (J) Relative abundances of the top five phyla in Dith+AP mice and Lyz+Dith+AP mice. (K) LDA scores at the genus level between Dith+AP mice and Lyz+Dith+AP mice. The data are presented as the means ± SD. ns, no significant difference; *, P ≤ 0.05.