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Proposed model of PAA signaling where antibiotic treatment leads to increased expression of the paa operon leading to decreased PAA levels, which ultimately regulates downstream responses such as Csu pili. Exogenous addition of PAA or 4F-PAA or the disruption of paaB can interfere with this response. We hypothesize that other conditions lead to decreased expression of the paa operon, meaning tight control of PAA levels is important for environmental adaptation of Acinetobacter.
