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Defining strain and lineage contributions to BCG vaccine escape. (A) Strategy for vaccinating and challenging mice and quantifying protection. (B) Difference in bacterial burden in the lung conferred by BCG vaccination over the course of the 4-week infection. Data represent mean replicate barcodes and SEM. (C) Protection conferred by BCG vaccination against mL2 strains compared to all other strains, with significance determined by Mann-Whitney U test.
