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Antibiotic treatment sensitizes mice to bloodstream infection with ESKAPE pathogens. Shown are survival curves of antibiotic-treated C57BL/6 mice infected i.v. with 5 × 107 CFU of clinical isolates of Klebsiella pneumoniae (A), the Enterobacter cloacae complex (B), Pseudomonas aeruginosa (C), Enterococcus faecium (D), and Acinetobacter baumannii (E) (n = 5 to 10 mice/group). Statistical analysis was performed using a log-rank (Mantel-Cox) test. *, P < 0.05; ***, P < 0.001.
