FIG 2.

Expression of human FcRn is not sufficient for echovirus infection by the enteral route in vivo. (A) Table of the six genotypes used in this study. Shown is the expression of mouse or human FcRn, IFNAR, and IFNLR among these genotypes. (B) Survival of the indicated genotype of mice inoculated with 10⁶ PFU of E5 by oral gavage for 7 days postinoculation. The log rank test was used to analyze the statistical differences of the survival rates. (C to H) At 3 dpi, animals were sacrificed, and viral titers in the stomach (C), duodenum (D), jejunum (E), ileum (F), large intestine (G), and stool (H) were determined by TCID₅₀ assays. In all panels, titers are shown as log₁₀ TCID₅₀ per milliliter, with the limit of detection indicated by a dotted line. Data are shown as means ± standard deviations, with individual animals shown as each data point. Data are shown with significance determined by a Kruskal-Wallis test with Dunn’s test for multiple comparisons (*, P < 0.05; **, P < 0.005; ***, P < 0.0005).