FIG 2.

Differentially regulated genes in response to meropenem treatment in A. baumannii. Heat maps show the fold changes in genes expressed at 0.5, 3, and 9 h of meropenem treatment relative to wild-type ATCC 17978 (P < 0.05). (A) Differentially regulated genes associated with efflux. (B) Dilution spot assays (in triplicate) of wild-type, ΔadeIJK, ΔompW, and ΔA1S_3492 strains with (+) or without (−) meropenem treatment. (C to G) Same as panel A but with pathway analysis including genes associated with outer membrane porins (C), outer membrane lipoproteins and their transporters (D), PG recycling (E), LOS biosynthesis (F), and PG biosynthesis (G).