FIG 5.

A working model of how the DnaK1/DnaJ3 chaperone system coordinates T4P activity and HPS production. Association of HmpF with the T4P motors activates cycles of pilus extension and retraction at the leading poles of cells. DnaK1 is subsequently recruited to the active motors via interaction with PilB and Hfq, where it forms a functional chaperone system influencing the folding state of an unidentified protein, which in turn influences the production of HPS. OM = outer membrane, PP = periplasm, CM = cytoplasmic membrane.