FIG 5.

Mtb PPE51 is required for persistence in vivo. Mycobacterial load in the lungs (A) and spleens (B) of C57BL/6J or TLR2^−/−mice infected via intranasal inoculation (∼200 CFU) with low doses of WT, Δ51, and Δ51C. Values are means and standard errors of the means (SEM) from two independent assays (n = 8 mice) and significance calculated by two-way ANOVA corrected by Dunnett's test for multiple comparisons. *, P < 0.05; ****, P < 0.0001. (B) Representative hematoxylin-and-eosin (H&E)-stained lung sections are shown for C57BL/6J or C57BL/6J TLR2^−/− mice at 4 weeks after infection with low dose intranasal of WT, Δ51, and Δ51C.