FIG 6.
Modeling principles of how AdpA regulates adpA and actII-4 expression. (A) In the absence of sulfane sulfur, PadpA is self-repressed by AdpA to form a negative-feedback loop, and hence, both PadpA strength and AdpA amount show a wave-like pattern. (B) Sulfane sulfur temporarily breaks the negative-feedback loop, which leads to a higher and longer expression of AdpA but not ActII-4 at the initial stage. After sulfane sulfur is consumed, the high AdpA level will lead to high expression of ActII-4. Equations and related parameters used for modeling are provided in Text S1.