FIG 7.
MAC13243 activity is independent of LolA. To test MAC13243 activity on LolA, OM permeability of strains in which chromosomal lolAB (lolAB+) are present or absent (ΔlolAB) was assessed. Strains carried either wild-type mreB or mreB(E143A) and were assessed upon treatment with increasing concentrations of MAC13243 and vancomycin. Data are from three independent experiments. Averaged density (A600nm) values of antibiotic-treated cultures relative to mock-treated control (set as 1.0) are shown.