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Directed evolution of DENV2 prM cleavage site in Vero and C6/36 cells. (A) Schematic of directed evolution from library generation to high-throughput sequencing. (B and C) Enrichment plots of prM cleavage site sequences from plasmid library to viral population at the third passage (P3) and the proportion, as well as sequence of the top 5 enriched sequences in C6/36 cells (yellow) (B) and Vero cells (cyan) (C).
