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Distances between Lys73 and the Ser70 Cβ. View from the active sites, with distances between Lys73 Nζ and the Cβ of Ser70 labeled in angstroms. (A) CTX-M-15:enmetazobactam cocrystal (yellow) overlaid with native CTX-M-15:tazobactam-derived acylenzyme (orange). (B) CTX-M-15K73A:enmetazobactam cocrystal (cyan) overlaid with uncomplexed CTX-M-15 (PDB code 4HBT [34]).
