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. 2022 May 31;13(3):e01321-22. doi: 10.1128/mbio.01321-22

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Copyright © 2022 Martins et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 5 — Colonic transcriptional response to infection with EHEC and commensal strains. Colonoid monolayers were infected for 6 h with EHEC, EHEC in the presence of commensals (EHEC+MC), or commensals only (MC), and transcriptomes were analyzed by RNA sequencing. (A) Total number of differentially expressed genes (DEGs) in infected colonoid monolayers versus mock controls. Red and blue indicate up- and downregulated genes, respectively. (B) Venn diagram showing the number of upregulated genes in each comparison (EHEC versus mock, EHEC+MC versus mock and MC versus mock). (C) Venn diagram showing the number of downregulated genes in each comparison. (D) Upregulated gene set enrichments showing the top 5 GO Biological Processes and KEGG pathways in infected colonoid monolayers over mock controls.