Graziani 2015.

Study characteristics
Methods	Study design: RCT with 2‐arm parallel design Recruitment period: July 2012–July 2013 Setting: university dental hospital, Pisa, Italy Number of centres: 1 Funding source: Unit of Dentistry and Oral Surgery of the University of Pisa and by the Italian Ministry Health and the Tuscan Region (Grant # GR‐2009‐1592229). FD holds a Clinical Senior Lectureship Award supported by the UK Clinical Research Collaboration. MO holds a UCL Impact Award partially supported with a fellowship grant by Johnson and Johnson Consumer Services EAME Limited. FD and MO work at UCL, which received a proportion of funding from the Department of Health's National Institute of Health Research (NIHR) Biomedical Research Centres funding scheme.
Participants	Inclusion criteria: diagnosis of chronic periodontitis* Exclusion criteria: medical disorders, SRP in past 6 months or on antibiotics from 3 months before or during study, smokers, pregnancy Age: FMS: 46 (SD 12) years; control: 48 (SD 9) years Sex: 19 F (FMS: 9; control: 10) and 19 M (FMS: 10; control: 9) Smokers: FMS: 7; control: 6 Number randomised: 38 (19 per group), all 'Caucasian' Number evaluated: 38 (19 per group)
Interventions	Comparison: FMS vs control FMS group: 2 session within 24 hours Control group: (SRP) QRP 4 sessions at 1‐week intervals OHI before study start: yes Instruments used: hand and US instruments Time per Q: unclear Maintenance: none Retreatment: none Duration of study: 3 months
Outcomes	Primary outcome: CRP increase Secondary outcomes: changes in a broad array of inflammatory and endothelial injury markers Teeth: whole‐mouth recordings with UNC‐15 manual probe Pocket depth at baseline: PPD > 4 mm Outcome time reported: 3 months used Other outcomes: PPD, CAL, BOP, PI (6 sites per tooth), body temperature
Notes	*Diagnosis provided by corresponding author on request.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated table.
Allocation concealment (selection bias)	Low risk	Quote: "Allocation to treatment was concealed to the clinical examiner and statistician with opaque envelopes which were opened by the clinician on the day of treatment".
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Examination by a blinded calibrated examiner, treatment by a single periodontist.
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants completed study.
Selective reporting (reporting bias)	Low risk	Data reported on all primary and secondary outcomes.
Other bias	Low risk	Baseline balance good for pocket depth. No apparent other biases.