Predin 2014.

Study characteristics
Methods	Study design: RCT with 2‐arm parallel design Recruitment period: unknown Setting: university dental hospital, Serbia Number of centres: 1 Funding source: research grant No. 175075 from the Ministry of Education and Science of Serbia
Participants	Inclusion criteria: diagnosis with chronic periodontitis Exclusion criteria: medical disorders, SRP in past 6 months or on antibiotics from 3 months before or during study, pregnancy Age: 32–75 years Sex: 31 F (FMS: 16; control: 15) and 9 M (FMS: 4; control: 5) Smokers: FMS: 4; control: 3 Number randomised: 48 (24 per group) Number evaluated: 40 (FMS: 21; control: 19), 8 dropouts (FMS: 3; control: 5) (Quote: "Subsequently, eight more patients were excluded from the study for various reasons")
Interventions	Comparison: FMS vs control FMS group: (FMRP) 2 sessions within 24 hours Control group: QRP 4 sessions at 1‐week intervals OHI before study start: yes Instruments used: hand and US instruments Time per Q: unclear Maintenance: none Retreatment: none Duration of study: 3 months
Outcomes	Primary outcome: unclear* Secondary outcomes: unclear* Teeth: whole‐mouth recordings (baseline, 1 and 3 months). Data split in initial moderate (PPD 5–7 mm) and deep pockets (PPD ≥ 7 mm). Williams manual probe Pocket depth at baseline: moderate (5 to < 7 mm), deep (≥ 7 mm) Outcome time reported: 3 months data used; 1 and 3 months measured Other outcomes: *PPD, CAL, BOP, PI, GI, PBI (4 sites per tooth), body temperature
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomisation performed with a computer‐generated list.
Allocation concealment (selection bias)	Low risk	Quote: "Patients were randomised into two groups according to a computer‐generated list provided by a person not involved in the study".
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Quote: "All the measurements have been conducted by the same investigator blind to the therapeutic protocol applied".
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Time point of dropout for each of the 8 participants unclear.
Selective reporting (reporting bias)	Low risk	All parameters have been reported.
Other bias	Low risk	Baseline balance good.