Quirynen 2006.

Study characteristics
Methods	Study design: RCT with 5‐arm parallel design (3 arms included) Recruitment period: unclear Setting: university dental hospital, Belgium Number of centres: 1 Funding source: supported by University
Participants	Inclusion criteria: diagnosis of chronic periodontitis with PD ≥ 6 mm. All participants in good general health Exclusion criteria: SRP in past 12 months or antibiotics from 4 months before or during study, compromised medical condition, pregnancy Age: 31–75 years. All Caucasian (assumed to be white people) Sex: 19 F (FMS: 10; FMD: 4; control: 5) and 24 M (FMS: 4; FMD: 10; control: 10) Smokers: 11 (FMS: 3; FMD: 3; control: 5) Number randomised: 85 in 5 arms Number evaluated: 43 in 3 arms (FMS: 14; FMD: 14; control: 15) (71 in 5 arms)
Interventions	Comparison: FMS vs control; FMD vs control; FMS vs FMD FMS group: (FRp): FMS 2 sessions over within 24 hours FMD group: (FM‐CHX): 2 sessions within 24 hours, after instrumentation: tongue brushing: CHX 1%, 1 minute; rinse: CHX 0.2%, 2 × 1 minute; spray pharynx: CHX 0.2%; subgingival: CHX 1%, 3 × within 10 minutes. Home: rinse CHX 0.2%, 1 minute, 2 × day, 2 months Control group: (NC): QRP 4 sessions scaling – 2‐week intervals, no antiseptics Groups not used in the review: 2 arms that were variations of the FMD intervention, i.e. amine fluoride/stannous fluoride for 2 months after full‐mouth scaling or chlorhexidine for the first 2 months followed by amine fluoride/stannous fluoride for another 6 months. OHI before study start: no Instruments used: hand instruments Time per Q: unclear Maintenance: 1, 2 and 4 months Retreatment: none Duration of study: 8 months
Outcomes	Primary outcome: PPD (6 sites per tooth) Secondary outcomes: CAL (as sum of PPD and GR), BOP (6 sites per tooth). Manual probe for all measurements Teeth: first Q recordings (baseline, 2, 4 and 8 months). Data split in single‐/multi‐rooted teeth and initial medium (PPD 4–5.5 mm) and deep pockets (PPD > 5 mm) Pocket depth at baseline: moderate (PPD 4.5–6.5 mm) and deep pockets (PPD ≥ 7 mm) Outcome time reported: 8 months used, 1, 2, 4* and 8 months measured Other outcomes: SBI, PI, GR (6 sites per tooth)
Notes	Dropouts: 85 enrolled, 71 completed the study. Time point for dropouts unclear. Only 3 arms of trial included. *Authors could not provide data for 4 months evaluation on request.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "A clinician who was informed about the baseline clinical data (but not about the content of the treatment strategies) randomly allocated (via a random‐number table) the consecutive participants (if fulfilling criteria) to one of the following groups".
Allocation concealment (selection bias)	Low risk	Quote: "A clinician who was informed about the baseline clinical data (but not about the content of the treatment strategies) randomly allocated (via a random‐number table) the consecutive participants (if fulfilling criteria) to one of the following groups".
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Treatment and examination by 2 independent people.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Dropouts 14/85; unclear reasons or timing of dropouts.
Selective reporting (reporting bias)	Low risk	Data reported on all primary and secondary outcomes.
Other bias	Low risk	Baseline balance good for pocket depth and smoking. No apparent other biases.