Swierkot 2009.

Study characteristics
Methods	Study design: RCT with 3‐arm parallel design Recruitment period: unclear Setting: university dental department, Marburg, Germany Number of centres: 1 Funding source: supported by university
Participants	Inclusion criteria: diagnosis of chronic periodontitis with PD ≥ 5 mm and BOP. All participants in good general health Exclusion criteria: antibiotics from 6 months before or during study, history of systemic disease, people attending for orthodontic treatment, pregnancy Age: 28–63 years Sex: 20 F (FMS: 7; FMD: 7; control: 6) and 5 M (FMS: 2; FMD: 2; control: 1) Smokers: 5 (FMS: 3; FMD: 1; control: 1) (smoking ≥ 10 cigarettes per day) Number randomised: 25 (FMS: 9 FMD: 9; control: 7) Number evaluated: 25 (FMS: 9 FMD: 9; control: 7)
Interventions	Comparison: FMS vs control; FMD vs control; FMS vs FMD FMS group: (FM‐SRP): 2 sessions within 24 hours FMD group: (FMD) 2 sessions scaling within 24 hours; after instrumentation: tongue brushing: CHX 1%, 1 minute; rinse: CHX 0.2%, twice for 1 minute; spray pharynx: CHX 0.2% 4 × each, subgingival: CHX 1%. Home: rinse CHX 0.2%, 1 minute, 2 × day, 14 days; spray tonsils: CHX 0.2%, 1 × day, 14 days Control group: (Q‐SRP) 4 sessions Q wise, 1‐week interval starting first Q, hand and US instruments OHI before study start: yes Instruments used: hand and US instruments Time per Q: unclear Maintenance: 1, 2, 4 and 8 months Retreatment: none Duration of study: 8 months
Outcomes	Primary outcome: PPD (4 sites per tooth) Secondary outcomes: CAL, BOP (4 sites per tooth). Manual probe for all measurements Teeth: whole‐mouth recordings (baseline, 1, 2, 4 and 8 months). Data split in single‐ and multi‐rooted teeth for moderate (4–6 mm) pockets and whole‐mouth recordings for deep (≥ 7 mm) pockets Pocket depth at baseline: moderate (PPD 4–6 mm) and deep pockets (PPD ≥ 7 mm) Outcome time reported: 4 and 8 months used. 1, 2, 4 and 8 months measured Other outcomes: PLI, API, microbiology
Notes	Blinding unclear. Exclusion of third molars, as well as teeth with furcation degree II and III
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "The randomisation was performed with a combination of coin toss and drawing of lots by a second person not involved in the study to assign the patients into the following groups: full mouth disinfection (FMD), FM‐SRP (FMS) and Q‐SRP (control)".
Allocation concealment (selection bias)	Low risk	Quote: "The sequence was concealed until interventions were assigned".
Blinding of outcome assessment (detection bias) All outcomes	High risk	Quote: "The treatment and reassessment were performed by one periodontist who had been trained and tested previously for his reproducibility".
Incomplete outcome data (attrition bias) All outcomes	Low risk	Quote: "One patient in every group was excluded from the study due to prescribed antibiotics because of sinusitis maxillaris. The patient of the FM‐SRP group dropped out 2 months after treatment and the two patients of the other two groups dropped out 4 months after treatment. Their data were not included into the statistical analysis".
Selective reporting (reporting bias)	Low risk	Data reported on all primary and secondary outcomes.
Other bias	Low risk	Baseline balance good for pocket depth and smoking. No apparent other biases.