Zijnge 2010.

Study characteristics
Methods	Study design: RCT with 2‐arm parallel design Recruitment period: September 2007–December 2008 Setting: private clinic, Groningen, The Netherlands Number of centres: 1 Funding source: university funding
Participants	Inclusion criteria: diagnosis of chronic periodontitis with PD ≥ 6 mm at > 10% sites. All participants in good general health Exclusion criteria: SRP over last 5 years, antibiotics from 3 months before or during study, pregnant, smokers, removable denture Age: 25–75 years Gender: 16 F (8 per group) and 22 M (FMS: 10; control: 12) Smokers: 0 Number randomised: 39 (FMS: 19; control: 20) Number evaluated: 38 (FMS 18; control: 20)
Interventions	Comparison: FMS vs control FMS group: (FM‐SRP) 1 × 3‐hour session Control group: (MS‐SRP): 3 sessions Q‐wise, 1‐hour duration per session, 10‐week interval starting first Q, hand instruments OHI before study start: no Instruments used: hand instruments Time per Q: 1 hour Maintenance: 1 and 2 weeks Retreatment: none Duration of study: 3 months
Outcomes	Primary outcome: PPD (6 sites per tooth) Secondary outcomes: BOP (6 sites per tooth). Manual probe for all measurements Teeth: whole‐mouth recordings as well as test‐Q (1st Q). Data split in moderate (4–6 mm) and deep (≥ 7 mm) pockets Pocket depth at baseline: moderate (PPD 4–6 mm) and deep pockets (PPD ≥ 7 mm) Outcome time reported: 3 months Other outcomes: PI, microbiology
Notes	PI at baseline unclear Pockets < 3 mm were not recorded. No data for CAL on request.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "a second independent person informed them whether they had to continue the treatment in the other quadrants (FM‐SRP) or continue treatment in another session (MS‐SRP), based on a computer‐generated randomisation table".
Allocation concealment (selection bias)	Low risk	Quote: "All study personnel was blinded to treatment assignment for the duration of the study".
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Quote: "After 3 months the patients were examined by a periodontist. All study personnel was blinded to treatment assignment for the duration of the study".
Incomplete outcome data (attrition bias) All outcomes	Low risk	Comment: 44 attended baseline examination but unclear if they were randomised. 1 participant dropped out of FMS group. Probably low risk of bias.
Selective reporting (reporting bias)	Low risk	Data reported on all outcomes.
Other bias	Low risk	Baseline balance good for pocket depth. No apparent other biases.

API: Approximal Plaque Index; AZ: azithromycin; BOP: bleeding on probing; CAL: clinical attachment level; CHX: chlorhexidine gluconate; DAS: Dental Anxiety Scale; DFS: Dental Fear Scale; F: female; FC: FMD with CHX; FM‐CHX: FMD with CHX; FM‐RP: see FMS; FM‐UD: FMS with ultrasonic instrumentation; FMD: full‐mouth disinfection (full‐mouth subgingival scaling and root planing with use of antiseptics); FM‐SRP: full‐mouth scaling and root planing; FMRP: FMS; FMS: full‐mouth scaling (full‐mouth subgingival scaling and root planing); FNC: FMD without CHX; FRp: FMS; GBI: Gingival Bleeding Index; GCF: gingival crevicular fluid; GI: Gingival Index (Löe 1963); GR: gingival recession; IL: interleukin; M: male; MGI: modified Gingival Index; MS‐SRP: multiple session scaling and root planing; NC: see QRP; OHI: oral hygiene instruction; PAL: probing attachment level; PBI: Papilla Bleeding Index; PD: probing depth; PD‐PIG: see FMD; PDG: see FMS; PI: Plaque Index (O'Leary 1972); PLI: Plaque Index (Silness 1964); PPD: probing pocket depth; PTQ‐TS: see QRP; PTSS: full‐mouth periodontal therapy; Q: quadrant; Q‐SRP: see QRP; QRP: quadrant‐wise subgingival scaling and root planing, clockwise in 4 sessions; RAL: relative attachment level; RCT: randomised controlled trial; SBI: Sulcus Bleeding Index; SD: standard deviation; SI: Staining Index; SRP: scaling and root planing; SRP‐Q: see QRP; SUP: suppuration; UNC: University of North Carolina; US: ultrasonic; VAS: visual analogue scale; VPI: Visible Plaque Index; VSC: volatile sulphuric compound; WTCI: Winkel Tongue Coating Index.