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. 2022 Jun 15;18(6):e1010225. doi: 10.1371/journal.pgen.1010225

Fig 1. 751 human SVAs are active in human pluripotent cells.

Fig 1

(A) Heatmaps depicting H3K9me3 ChIP-seq signal at all human SVAs in iPSCs. (B) ChIP-seq for H3K9me3 in human NCCITs at SVA regions previously classified as repressed and de-repressed in human iPSCs. (C) Average profiles of H3K9me3 enrichment at SVAs repressed in human iPSCs and NCCITs. (D) ChIP-seq for H3K27ac in NCCIT cells. The heatmap is centered on the 751 de-repressed SVAs. (E) Barplot representing the number of total repressed and de-repressed human SVAs (i.e. SVAs decorated with H3K9me3 versus lacking H3K9me3). 2982 of the ~3700 human SVAs were repressed, while 751 were de-repressed. (F) & (G) Human-specific SVAs, subfamilies SVA-E and -F are enriched within the de-repressed SVA population.