Table 2.
Comparison between the pretreatment and posttreatment values in patients with ISSNHL
| Characteristics | NAC, N = 94 (%) | Non-NAC, N = 125 (%) | ||||
|---|---|---|---|---|---|---|
| Pretreatment | Posttreatment | P value | Pretreatment | Posttreatment | P value | |
| 250 Hz, dB ± SD | 69.7 ± 24.6 | 35.3 ± 21.7 | <.001* | 71.8 ± 22.2 | 40.3 ± 26.5 | <.001* |
| 500 Hz, dB ± SD | 74.8 ± 22.7 | 37.6 ± 20.0 | <.001* | 78.6 ± 20.1 | 45.7 ± 27.9 | <.001* |
| 1k Hz, dB ± SD | 77.6 ± 20.6 | 48.2 ± 20.4 | <.001* | 82.3 ± 20.4 | 55.6 ± 29.7 | <.001* |
| 2k Hz, dB ± SD | 74.6 ± 22.1 | 51.2 ± 23.6 | <.001* | 76.8 ± 24.4 | 56.4 ± 28.7 | <.001* |
| 4k Hz, dB ± SD | 79.1 ± 21.8 | 53.9 ± 23.9 | <.001* | 80.2 ± 25.3 | 58.0 ± 32.7 | <.001* |
| 8k Hz, dB ± SD | 81.7 ± 18.6 | 54.2 ± 24.4 | <.001* | 79.3 ± 25.2 | 60.9 ± 34.1 | <.001* |
| Mean hearing level, dB ± SD | 76.3 ± 18.4 | 46.7 ± 16.3 | <.001* | 78.1 ± 20.0 | 52.8 ± 26.9 | <.001* |
| Tympanometry type A | 92 (97.8) | 94 (100.0) | .497 | 122 (97.6) | 125 (100.0) | .247 |
| Tympanometry type B | 2 (2.2) | 0 (0.0) | .497 | 3 (2.4) | 0 (0.0) | .247 |
| Tympanometry type C | 0 (0.0) | 0 (0.0) | 1.000 | 0 (0.0) | 0 (0.0) | 1.000 |
| SRT, dB ± SD | 74.5 ± 23.4 | 48.2 ± 22.7 | <.001* | 72.9 ± 25.6 | 54.0 ± 31.2 | <.001* |
| SDS, % ± SD | 44.4 ± 21.3 | 70.0 ± 27.0 | <.001* | 44.7 ± 18.7 | 68.0 ± 29.0 | <.001* |
ISSNHL = idiopathic sudden sensorineural hearing loss, mean hearing level = average pure tone audiometry (PTA) at 500, 1k, 2k, and 4k Hz, N = numbers, NAC = N-acetylcysteine, SD = standard deviation, SDS = speech discrimination score, SRT = speech reception threshold.
*
P < .05.