Appendix 2—table 3. Optimized parameters for each patient resulting from nonlinear constrained optimization.

Patient	${\displaystyle {\mathit{x}}_{\mathit{S}}(\mathbf{0})}$	${\displaystyle {\mathit{x}}_{\mathit{R}}(\mathbf{0})}$	${\displaystyle {\mathit{\alpha }}_{\mathit{R}\mathit{S}}}$	${\displaystyle {\mathit{\beta }}_{\mathit{S}C}}$
P1001	86.74	1.00	6	8
P1002	165.99	24.67	6	8
P1003	10000.00	124.98	6	8
P1004	19.90	400.57	6	8
P1005	802.20	12.31	6	8
P1006	102.28	174.59	6	8
P1007	253.07	149.12	6	8
P1009	20.41	23.61	6	8
P1010	196.09	1001.19	6	8
P1011	29.19	6.31	6	8
P1012	567.60	663.13	6	8
P1014	1640.76	273.61	6	8
P1015	126.13	6.38	6	8
P1016	4589.21	4078.11	6	8
P1017	6035.16	4060.25	6	8
P1018	1495.72	318.18	6	8
P1020	2061.34	477.07	6	8
C001	111.70	19.46	6	8
C002	1867.68	1.00	6	8
C003	61.96	5.81	6	8
C004	110.57	156.36	6	8
C005	66.07	127.48	6	8
C006	1226.45	25.31	6	8
C007	1740.08	1325.03	6	8
C008	4362.58	24.08	6	8
C009	148.30	936.54	6	8
C010	273.95	798.61	6	8
C011	19.85	129.22	6	8
C012	2148.71	301.47	6	8
C013	165.20	31.48	6	8
C014	13.57	5.09	6	8
C015	1211.43	483.69	6	8