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. 2022 Jan 19;31(12):2063–2077. doi: 10.1093/hmg/ddac012

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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RNA-Seq from prostate tissue reveals aberrant RNA splicing in the exons 3–5 region of ANO7. Benign and cancer prostate tissue from a non-carrier (PrCa-2.88), a heterozygous carrier (PrCa-11.55) and a homozygous carrier (PrCa-8.67) are shown. The coverages shown as bar graphs are not to scales between samples. (A) RNA read coverage across the ANO7 gene. The reference transcripts corresponding to ANO7-L and ANO7-S as well as the introns 3–5, 18, 19 and 22 are marked. The red line across the transcripts marks the position of rs77559646. (B) Sashimi plots across the exons 3–7 region. The arcs represent the splice junctions, the line thickness increase with the number of reads (indicated) split across the junction.