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. 2022 Jan 19;31(12):2063–2077. doi: 10.1093/hmg/ddac012

Figure 3.

Figure 3

Splicing cluster in ANO7 identified by LeafCutter to be significantly differentially spliced in carriers compared to non-carriers. (A) The exons 3–5 cluster differs among the cancer samples. The original ‘Fraction of junction’ values printed by the LeafCutter’s LeafViz R shiny application have been manually replaced with ΔPSI (percent spliced in) values. The letters a-j denote the ranking of the events performed by the tool. (B–D) Sanger sequencing of RT-PCR products across aberrant splicing events. (B) Splicing from exon 3 to exon 5, junction a. (C) Splicing from exon 3 to position 241 192 002 in intron 3, junction e. (D) Splicing from exon 3 to position 241 197 672 in intron 4, junction d.